Brain Cancer: December 2006 Archives

Eli Lilly stops trial of brain cancer drug

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brain cancer BOSTON, Dec 21 (Reuters) - Eli Lilly & Co. (LLY.N) said on Thursday that it has stopped a trial of its experimental brain cancer drug after a monitoring committee determined the treatment would probably prove no more effective than chemotherapy in delaying progression of the disease.

Lilly said an interim analysis of data from a late-stage, or Phase III, study suggested the drug, enzastaurin, would not stave off an aggressive and recurrent form of brain cancer known as recurrent glioblastoma any better than chemotherapy.

The company said it will continue enrolling patients in a late-stage trial to evaluate enzastaurin as a potential treatment for non-Hodgkin's lymphoma. It will also continue mid-stage trials of the drug in other cancers, such as breast, colon, lung, ovarian and prostate.

source - Reuters 

Brain cancer study may lead to therapy

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brain cancerBALTIMORE, MD, United States (UPI) -- U.S. and Italian scientists have inhibited human brain cancers in mice by inducing positive changes in cells behaving as cancer stem cells.

The most common type of brain cancer -- glioblastoma -- is marked by the presence of the stem cell-like brain cells, which, instead of triggering the replacement of damaged cells, form cancer tissue.

Researchers from Johns Hopkins University and the University of Milan in Italy used bone morphogenic proteins, which cause neural stem cell-like clusters to lose their stem cell property, which, in turn, stops their ability to divide.

New Research Yields Clues to Brain Cancer

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brain cancerHealthDay News -- Armed with findings from experiments in mice, researchers say they've gained key insights into potential treatments for the deadliest form of brain cancer.

Italian and American scientists say they've identified a protein that may reduce tumor growth by targeting cells that help bring cancer to life.

There aren't any immediate ramifications for doctors and patients. However, "we have identified a novel strategy for the treatment of malignant, incurable human brain tumors which could potentially lead to more effective therapies," said Angelo L. Vescovi, lead author of the study and a researcher at University of Milan-Bicocca in Italy.

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This page is a archive of entries in the Brain Cancer category from December 2006.

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