General Cancer News: March 2007 Archives

Scientists surveying the human genome have found that many more gene mutations drive the development of cancer than previously thought.

The survey is reported in the journal Nature.

In the largest survey of its kind, an international team comprising over 60 scientists from the UK, Hong Kong, the Netherlands, Belgium, USA and Australia, working for the Cancer Genome Project, examined more than 500 genes and 200 cancers and sequenced more than 250 million letters of DNA code.

They found about 120 new genes that drive the development of cancer cells.

A gene that prevents cancer also controls the skin's suntanning machinery, researchers report in the March 9, 2007 issue of the journal Cell.

"The p53 tumor suppressor is commonly mutated in human cancer," explained David Fisher, director of the Melanoma Program in Medical Oncology at Dana-Farber Cancer Institute. "Now, we've found that it plays a role in the skin's tanning response."

The researchers also linked the p53-driven process to other instances of skin darkening not associated with the sun

People at average risk for colon cancer shouldn't take aspirin or painkillers like ibuprofen to try to prevent the disease, a federal task force advises, because of the risk of bleeding and other potential health problems.

The recommendation for the first time by the US Preventive Services Task Force includes those with a family history of colorectal cancer.

The panel said that potential risks of taking more than 300 milligrams a day of aspirin or non-steroidal anti-inflammatory drugs, such as ibuprofen and naproxen - brand names include Motrin, Advil and Aleve - include a higher risk for stroke, intestinal bleeding or kidney failure.