Lung Cancer: October 2006 Archives

by Kristina Collins, The Cancer Blog, 27 Oct 2006

Celebrex (celecoxib) does not seem to show any benefit in patients receiving second line chemotherapy for lung cancer. Second line chemotherapy refers to treatment given when the initial treatment does not work or stops working.

According to the results of a phase II clinical trial published in the Journal of Clinical Oncology, the effectiveness of Celebrex is not seen when added to chemotherapy for patients with non-small cell lung cancer (NSCLC). Researches conducted the trial among 133 patients with stage IIIB or Stage IV NSCLC. Aside from pain, the addition of Celebrex did not improve patient symptoms or outcomes. One year survival was 24 percent among patients treated with Celebrex and chemotherapy and 36 percent among patients treated with chemotherapy alone.

Rockville biotech begins human trials on lung cancer drug


EntreMed has launched a first round of human trials on lung cancer patients for a drug already in clinical tests to battle other forms of cancer.

The Rockville company is starting Phase I trials of MKC-1, its small-molecule drug to treat lung cancer -- the same drug it began testing in Phase I for leukemia one month ago and in Phase II trials for advanced breast cancer 10 months ago.

The lung-cancer trial is taking place at various medical centers, but the lead institution is Indiana University Cancer Center, which is also a site for EntreMed's trials of another drug candidate, Panzem, which treats advanced breast and prostate cancer.

The Irish Cancer Society is calling on the Government to increase the price of 20 cigarettes by at least €2 in this December's budget.

The society, which makes a similar call every year, says increasing the price is the most effective way of encouraging people to quit the habit and discouraging them from starting in the first place.

However, the Government is usually reluctant to introduce massive price increases due to the effect it would have on inflation

The Cancer Society claims the number of young smokers, particularly girls, is currently increasing because the price of cigarettes has not been increased in the last two budgets.


Give up or we won't operate, smokers told


Smokers will be denied life-changing operations unless they agree to kick the habit, it was revealed today.

Cash-strapped hospitals say patients will not be given treatments such as hip and knee replacements until they try to give up. Those who fail could be denied treatment all together.

Managers in Norfolk and Newcastle, where trusts are millions of pounds in debt, say smokers are at a greater risk of complications and the move will help save them money on further care.

Eli Lilly and Company has launched a major clinical trial evaluating ALIMTA (pemetrexed for injection) in extensive stage small cell lung cancer (SCLC), a devastating and rapidly spreading form of lung cancer. SCLC is sometimes called oat cell cancer because small cell lung cancer cells resemble oat grains. Patients with SCLC are staged according to a two-stage system, being diagnosed as having either limited stage disease or extensive stage disease. About 65 to 70 percent of patients with SCLC are diagnosed with extensive stage disease and the current two year survival rate is less than 10 percent.

by Dalene Entenmann, The Cancer Blog, 22 Oct 2006

The local chapter of the New York City American Cancer Society is asking that candy-flavored cigarettes be banned from sale because they feel it is a tobacco industry marketing ploy to appeal to teens. During a City Council meeting, the bill introduced would prohibit the sale of cigarettes with fruity flavors, like Twista Lime, and Midnight Berry; candy flavors like Warm Winter Toffee; and any cigarettes with flavors resembling chocolate, vanilla, honey, candy, mint, cocoa, dessert, or an alcoholic beverage.

But is this the way to go?

Key To Lung Cancer Chemo Resistance Revealed


Scientists at Johns Hopkins have discovered how taking the brakes off a "detox" gene causes chemotherapy resistance in a common form of lung cancer.

Products made by a gene called NRF2 normally protect cells from environmental pollutants like cigarette smoke and diesel exhaust by absorbing the materials and pumping them out of the cell. Another gene called KEAP1 encodes products that stop this cleansing process. But lung cancer cells sabotage the expression of these same genes to block assault from chemotherapy drugs.

Progress in field of lung cancer is mostly modest


by Jacki Donaldson, 13 Oct 2006

Dr. Chandra Belani, Professor of Medicine and Oncology at the University of Pittsburg Cancer Institute, is a leader in the study of lung cancer. During a podcast interview, Belani shares some thoughts on the state of lung cancer -- currently the most common cause of cancer death in the United States.

Bar workers' better lung function post ban


DUNDEE, Scotland, Oct. 11 (UPI) -- Scottish bar workers showed significant improvement in respiratory and lung function within two months following a ban on smoking in confined public places.

Daniel Menzies and colleagues from Ninewells Hospital and Medical School in Dundee, Scotland, examined the effect of the recently introduced smoke-free legislation on bar workers' health in Scotland.

Reynolds to drop flavored cigarettes


By Michael Gormley, AP, 11 Oct 2006

ALBANY, N.Y. - R.J. Reynolds has agreed to a domestic ban on flavored cigarettes such as "Twista Lime" and "Mocha Taboo" that critics say are marketed to youths, officials from 38 states and a U.S. territory said Wednesday.

The tobacco giant settled the broad investigation of domestic sales of the flavored products without paying any penalty. The company agreed to stop identifying cigarettes with candy, fruit, desserts or alcoholic beverage names, imagery or ads, according to a statement from New York Attorney General Eliot Spitzer. The company will also stop using scented promotional material, including scrach-and-sniff samples.

U.S. OKs use of Genentech's Avastin in lung cancer


By Deena Beasley, 11 Oct 2006

LOS ANGELES (Reuters) - U.S. regulators agreed to expand the use of Genentech Inc.'s drug Avastin, now used against colon cancer, to include treatment of the most common type of lung cancer, the company said on Wednesday.

Avastin, the first drug designed to starve tumors of blood and nutrients, was approved as an initial treatment, in combination with chemotherapy, for patients with non-small cell lung cancer.

Nonsmokers Can Inherit Lung Cancer


Oct. 9, 2006 -- Having a close family member who's had lung cancer doubles your own risk for the disease -- even if you don't smoke.

The finding comes from a 13-year study of more than 102,000 Japanese men and women. Study participants were aged 40 to 69 at the start of the study. Over the study period, nearly 800 participants developed lung cancer.

France bans smoking in many public areas


PARIS - The days of cigarette-friendly France are about to go up in smoke

The prime minister announced Sunday that a ban on smoking in schools, offices and other public buildings will start in February, while restaurants, dance clubs and some bars have until 2008 to comply.

"I am convinced the French people are now ready," said Dominique de Villepin, joining Ireland, Spain, Britain and Italy which have adopted similar measures. "The issue is ripe in our country, given the experiences that we know of elsewhere."

Lung Cancer Epidemic from DU has begun in U.S.


By Dr. James Howenstine, MD., 6 Apr 2006

In the first 2 months of 2006 there were 172,000 cases of lung cancer[ Reference: CNN American Morning Program March 8, 2006 Miles and Soledad O'Brien] in the U.S. The whole year of 2005 only saw 175,000 cases of lung cancer. How can this be explained? This does not fit with inhalation of second hand smoke or cigarette smoking. High levels of uranium were found in the air at the Aldermaston research Center in northern England ten days after the second war in Iraq began with heavy bombing and shelling in Iraq. This suggests that all of Europe was contaminated with radiation at the onset of Gulf War II. There have now been 4 nuclear wars since World War II (Iraq twice, Afghanistan, Bosnia).The amount of radiation released since 1991 is greater than the equivalent radiation of 82,000 Nagasaki type nuclear devices. No news media in Europe or the U.S. discusses this as this is one of many forbidden topics.

About this Archive

This page is a archive of entries in the Lung Cancer category from October 2006.

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